Advances in Mitochondrial Medicine.pdf

Advances in Mitochondrial Medicine PDF

Roberto Scatena

Mitochondria are far more than the powerhouse of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of mitochondrial medicine, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called mitoxicants are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

1. J Intern Med. 1999 Jul;246(1):11-23. Mitochondrial medicine--recent advances . Graff C(1), ... May 11, 2020 ... PDF | On Jan 1, 2018, Gregory M. Enns Enns and others published Advances in Mitochondrial Medicine | Find, read and cite all the research ...

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Advances in Mitochondrial Medicine.pdf

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Sofya Voigtuh

Mitochondrial diseases: advances and issues Mauro Scarpelli,1 Alice Todeschini,2 Irene Volonghi,2 Alessandro Padovani,2 Massimiliano Filosto2 1Department of Neuroscience, Unit of Neurology, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy; 2Center for Neuromuscular Diseases and Neuropathies, Unit of Neurology, ASST “Spedali Civili”, University of Brescia, Brescia Mitochondrial medicine - Orphanet

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Mattio Müllers

Advances in mitochondrial medicine - …

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Noels Schulzen

Clinical trials are a key component of clinical research and are at the heart of all medical advances in mitochondrial disease. A clinical trial or study adds to ... Sep 7, 2018 ... A recap of the UMDF's Mitochondrial Medicine 2018 conference in ... will make new discoveries and clinical advances in the year ahead.

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Jason Leghmann

Advances in Mitochondrial Medicine | SpringerLink Advances in Mitochondrial Medicine. Editors (view affiliations) Roberto Scatena; Patrizia Bottoni; Bruno Giardina ; Book. 958 Citations; 46 Mentions; 116k Downloads; Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 942) Log in to check access. Buy eBook. USD 179.00 Instant download; Readable on all devices; Own it forever; Local sales tax included if

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Jessica Kolhmann

Get this from a library! Advances in mitochondrial medicine. [Roberto Scatena; Patrizia Bottoni; B Giardina;] -- Mitochondria are far more than the powerhouse of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to … Advances in Mitochondrial Medicine - Google Books