Advances in Mitochondrial Medicine.pdf

Advances in Mitochondrial Medicine PDF

Roberto Scatena

Mitochondria are far more than the powerhouse of the cell as they have classically been described. In fact, mitochondria biological activities have progressively expanded to include not only various bioenergetic processes but also important biosynthetic pathways, calcium homeostasis and thermogenesis, cell death by apoptosis, several different signal transduction pathways mainly related to redox control of gene expression and so on. This functional and structural complexity may undergo important derangements so to justify the definition of mitochondrial medicine, which should include all the clinical consequences of congenital or acquired mitochondrial dysfunctions. There are actually a growing number of studies which assign a significant pathogenic role to damaged mitochondria in different diseases: ischemia/reperfusion injury, neurodegenerative diseases, cancer with its dramatic sequelae (i.e, metastasis), metabolic syndrome, hyperlipidemias, just to mention a few of the most important pathologies. In this context, a further aspect that should not be disregarded is the interaction of pharmacological agents with mitochondria, not only in regard of the toxicological aspects but, above all, of the potential therapeutic applications. In fact, it is interesting to note that, while the properties of different so-called mitoxicants are well-known, the subtle linkages between drugs and mitochondria is still in need of a real pharmacological and therapeutic control at the clinical level. This lack of consideration can often lead to an underestimation of unwanted toxic effects but also of desirable therapeutic activities. A reevaluation of the potential clinical role of mitochondria could give a new light on some yet obscure aspects of human pathophysiology.

Foundation for Mitochondrial Medicine (FMM) - Simply put, our purpose is to ... Many drug trials take years -- and treatment advances happen one small step at a ... May 5, 2014 ... ... entitled, Advances in Mitochondrial Medicine. The editors point out that mitochondria are far more than the “powerhouse” of the cell as they ...

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Advances in Mitochondrial Medicine.pdf

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Notes actuelles

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Sofya Voigtuh

Advances in Mitochondrial Medicine | Request PDF Request PDF | On Jan 1, 2012, ROBERTO SCATENA and others published Advances in Mitochondrial Medicine | Find, read and cite all the research you need on ResearchGate

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Mattio Müllers

LEADER: 04321cam a2200541Ka 4500: 001: 1365511: 005: 20120531121354.0: 006: m d : 007: cr cnu---unuuu: 008: 120321s2012 ne o 001 0 eng d: 010

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Noels Schulzen

Clinical trials are a key component of clinical research and are at the heart of all medical advances in mitochondrial disease. A clinical trial or study adds to ... Sep 7, 2018 ... A recap of the UMDF's Mitochondrial Medicine 2018 conference in ... will make new discoveries and clinical advances in the year ahead.

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Jason Leghmann

Mitochondrial medicine. 4 5 Mitchondrial medicine a clinical guideline Saskia Koene & Jan Smeitink Contributors: Prof. Michio Hirano, New York Prof. An Lombes, Paris Prof. Shamima Rahman, London Prof. Eric Shoubridge, Montreal Prof. Izelle Smuts, Pretoria Prof. David Thorburn, Melbourne Prof. Doug Turnbull, Newcastle Upon Tyne Prof. Anu Wartiovaara-Suomalainen, Helsinki Prof. Jiri Zeman Mitochondria are far more than the “powerhouse” of the cell as they have classically been described. In fact, mitochondria biological activities have progressively ...

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Jessica Kolhmann

Table of Contents: Advances in mitochondrial …